The Patron Saint of the school is St. Katherine of Siena. Her feast day is on the 29th of April. This is celebrated as St. Karen’s Day.

The school has derived its name from the novel KAREN written by Marie Lyons Killilea. ‘KAREN’ is the inspiring true story of a little girl who triumphed over disaster and her delightful family who made her triumph possible. Imbued with the same spirit of sacrifice, love, devotion and care for children, St. Karen’s was established.

St. Karen’s High School is a minority Anglo-Indian Christian institution, by reason of both religion and language. The School has been established by The Anglo–Indian Educational Society of St. Karen’s, which is a registered body. This Society was established solely for the educational and cultural development primarily of Anglo–Indian Christian Children seeking the same and admitting inter alia such other children irrespective of caste, creed, location, language, sex or religion as are desirous of receiving education at St. Karen’s High School.